One lone missense mutation in Dyrk1B gene ( R102C ) was found associated with an autosomal dominant early onset Coronary Artery Disease, juvenile-onset truncal obesity, severe hypertension, and type II diabetes mellitus-seen in subjects from a nomadic group in Iran.
2.
:Cushing's disease may cause fatigue, weight gain, fatty deposits around the abdomen and lower back ( truncal obesity ) and face ( " moon face " ), stretch marks ( striae ) on the skin of the abdomen, thighs, breasts and arms, hypertension, glucose intolerance and various infections.
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